Efficient synthesis of multifunctional furanoid C-glycoamino acid precursors

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• 作者：Vera-Ayoso ; Yolanda ; Borrachero ; Pastora ; Cabrera-Escribano ; Francisca ; G??mez-Guill??n ; Manuel
• 刊名：Tetrahedron: Asymmetry
• 出版年：2005
• 出版时间：February 21, 2005
• 年：2005
• 卷：16
• 期：4
• 页码：889-897
• 全文大小：203 K

文摘

Ready access to constrained, multifunctionalized, hydrolytically stable amino acids has been established by the synthesis of their direct precursors using 2,5-anhydro-3-azido-3-deoxy-d-altrose (a aaaformyl azido-C-glycofuranosideaaa), or its readily available, stable synthetic equivalent [(1R) and (1S)-2,5-anhydro-3-azido-4,6-O-benzylidene-3-deoxy-1-fluoro-1-O-methyl-d-altritol], as novel molecular scaffolds.