Unique Requirement for ESCRT Factors in Flavivirus Particle Formation on the Endoplasmic Reticulum
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- 作者：Keisuke Tabata1 ; Masaru Arimoto1 ; Masashi Arakawa2 ; Atsuki Nara3 ; Kazunobu Saito4 ; Hiroko Omori4 ; Arisa Arai2 ; Tomohiro Ishikawa5 ; Eiji Konishi6 ; 7 ; Ryosuke Suzuki8 ; Yoshiharu Matsuura9 ; Eiji Morita1 ; 2 ; 10 ; moritae@hirosaki-u.ac.jp" class="auth_mail" title="E-mail the corresponding author
- 关键词：flavivirus ; ESCRT ; TSG101 ; CHMP2 ; CHMP4
- 刊名：Cell Reports
- 出版年：2016
- 出版时间：30 August 2016
- 年：2016
- 卷：16
- 期：9
- 页码：2339-2347
- 全文大小：2972 K
文摘
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Several ESCRT subunits are recruited to sites of flavivirus replication on the ER
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Systematic siRNA screening identifies a unique requirement for ESCRT factors
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Essential ESCRT subunits, VPS4 and ALIX, are dispensable for flavivirus replication
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ESCRT depletion affects virual budding but not the genome replication