A Critical Role of IL-21-Induced BATF in Sustaining CD8-T-Cell-Mediated Chronic Viral Control
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- 作者：Gang Xin1 ; David M. Schauder1 ; 2 ; Begoñ ; a Lainez5 ; Jason S. Weinstein3 ; Zhengxi Dai1 ; Yuhong Chen1 ; Enric Esplugues5 ; Renren Wen1 ; Demin Wang1 ; Ian A. Parish4 ; Allan J. Zajac6 ; Joe Craft3 ; Weiguo Cui1 ; 2 ; weiguo.cui@bcw.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：IL-21 ; BATF ; STAT3 ; IRF4 ; Blimp-1 ; CD8 T cell ; LCMV
- 刊名：Cell Reports
- 出版年：2015
- 出版时间：10 November 2015
- 年：2015
- 卷：13
- 期：6
- 页码：1118-1124
- 全文大小：2053 K
文摘
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CD4-derived IL-21 sustains CD8 T cell antiviral response in a temporal manner
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IL-21-induced BATF is required to sustain virus-specific CD8 T cell function
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BATF overexpression sufficiently rescues “unhelped” CD8 T cells
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BATF and IRF4 cooperatively regulate Blimp-1 expression and effector T cell function