A stable epoxide of estrone: Evidence for formation of a ‘new’ estrogen metabolite

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• 作者：James I. Raeside ; ^{jraeside@uoguelph.ca} ; Heather L. Christie
• 关键词：Estrone ; Epoxide ; Stable metabolite ; Radioactive steroids ; Tissue incubations ; 6α-Hydroxy-estrone
• 刊名：The Journal of Steroid Biochemistry and Molecular Biology
• 出版年：2017
• 出版时间：March 2017
• 年：2017
• 卷：167
• 期：Complete
• 页码：39-47
• 全文大小：1709 K
• 卷排序：167

文摘

Evidence for a “new” metabolite of estrone is described. Radiolabeled metabolite tentatively identified as 5α,6α-epoxy-estrone. Formation of an “unknown” estrogen metabolite by a wide range of non-hepatic tissues. An alternative to catechol estrogen formation is suggested.