The impact of lemon pectin characteristics on TLR activation and T84 intestinal epithelial cell barrier function
详细信息 查看全文
- 作者：Leonie M. Vogta ; Neha M. Sahasrabudhea ; Uttara Ramasamyb ; Diederick Meyerc ; Gerdie Pullensd ; Marijke M. Faasa ; e ; Koen Venemaf ; Henk A. Scholsb ; Paul de Vosa ; p.de.vos@umcg.nl" class="auth_mail" title="E-mail the corresponding author
- 关键词：DDM ; digested pectin with degree of methyl esterification ; DM ; degree of methyl esterification ; DP ; degree of polymerization ; ECIS ; electric cell substrate impedance sensing ; GalA ; galacturonic acid ; GM-CSF ; granulocyte macrophage-colony stimulating factor ; HEK ; human embryonic kidney ; HPAEC ; high performance anion exchange chromatography ; HPSEC ; high pressure size exclusion chromatography ; Mw ; molecular weight ; AP1 ; activator protein 1 ; NSAID ; non-steroid anti-inflammatory drug ; OVA ; ovalbumin
- 刊名：Journal of Functional Foods
- 出版年：2016
- 出版时间：April 2016
- 年：2016
- 卷：22
- 期：Complete
- 页码：398-407
- 全文大小：1073 K
文摘
- •
Stimulation with lemon pectins induces activation of TLR2, TLR4 and NF-κB.
- •
An intact pectin backbone is essential for TLR activation.
- •
Degree of methyl esterification of the backbone determines activation strength.
- •
Lemon pectins demonstrate strong protection on epithelial cell barrier.
- •
Lemon pectins are thus promising ingredients for health improving functional foods.