Filovirus proteins for antiviral drug discovery: A structure/function analysis of surface glycoproteins and virus entry
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- 作者：Baptiste Martina ; Thomas Hoenenb ; Bruno Canarda ; Etienne Decrolya ; etienne.decroly@afmb.univ-mrs.fr" class="auth_mail" title="E-mail the corresponding author
- 关键词：Ebola ; Filovirus ; Antiviral ; Mononegavirales ; Entry inhibitors ; Glycoprotein
- 刊名：Antiviral Research
- 出版年：2016
- 出版时间：November 2016
- 年：2016
- 卷：135
- 期：Complete
- 页码：1-14
- 全文大小：2257 K
文摘
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The filovirus surface glycoprotein is the key player protein responsible for viral entry.
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Secreted forms of the glycoprotein have been suggested to participate to filovirus virus pathogenicity.
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Recent structural insights of the filovirus surface glycoprotein highlight new antiviral perspectives.
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Interesting compounds and innovative antiviral strategies emerge from research and development to inhibit filovirus entry.