Facile synthesis of d-amino acids from an l-serine-derived aziridine

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• 作者：Travins ; Jeremy M. ; Etzkorn ; Felicia A.
• 关键词：amino acids and derivatives ; aziridines ; copper and compounds ; asymmetry
• 刊名：Tetrahedron Letters
• 出版年：1998
• 出版时间：December 17, 1998
• 年：1998
• 卷：39
• 期：51
• 页码：9389-9392
• 全文大小：218 K

文摘

Using the concept that l-serine can be converted into a desymmetrized γ-diol derivative, five d-amino acids were synthesized from a common aziridine intermediate by a general, high-yielding three-step process. The key 2-t-butyldimethylsiloxymethyl N-t-butoxycarbonyl aziridine intermediate was synthesized in four steps and 65 % overall yield.