刊名:Biochemical and Biophysical Research Communications
出版年:2017
出版时间:22 January 2017
年:2017
卷:482
期:4
页码:994-1000
全文大小:1926 K
卷排序:482
文摘
Transcriptional regulation of EVI1 in CML-BC is proposed. EVI1 transcription is directly regulated by LEF1/β-catenin complex in CML-BC. Loss of p53 function as a key regulator for β-catenin-EVI1 in CML myeloid-BC. The LEF1/β-catenin binding site on the EVI1 promoter is a new target for CML-BC.