- 作者：Kiyomi Matsuo ; Ichiro Morioka ; Mai Oda ; Yoko Kobayashi ; Yuji Nakamachi ; Seiji Kawano ; Miwako Nagasaka ; Tsubasa Koda ; Tomoyuki Yokota ; Satoru Morikawa ; Akihiro Miwa ; Akio Shibata ; Toshio Minematsu ; Naoki Inoue ; Hideto Yamada ; Kazumoto Iijima
- 关键词：Auditory brainstem response ; Cytomegalovirus infection ; Evans&rsquo ; index ; Lateral ventricle width/hemispheric width ratio ; Ventricle
- 刊名：Brain and Development
- 出版年：January, 2014
- 年：2014
- 卷：36
- 期：1
- 页码：10-15
- 全文大小：491 K
Background
Infants with congenital cytomegalovirus infection (CCMVI) may develop brain abnormalities such as ventricular dilatation, which may potentially associate with sensorineural hearing loss. There is currently no recognized method for quantitative evaluation of ventricle size in infants with CCMVI. Our objectives were to establish a method for quantitative evaluation of ventricle size using computed tomography (CT) in infants with CCMVI, and determine a cut-off value associated with abnormal auditory brainstem response (ABR) early in life.Design/Subjects
This study enrolled 19 infants with CCMVI and 21 non-infected newborn infants as a control group. Infants with CCMVI were divided into two subgroups according to ABR at the time of initial examination: normal ABR (11 infants) or abnormal ABR (8 infants). Ventricle size was assessed by calculating Evans鈥?index (EI) and lateral ventricle width/hemispheric width (LVW/HW) ratio on brain CT images, and was compared among groups. A cut-off ventricle size associated with abnormal ABR was determined.
Results
EI and LVW/HW ratio were significantly higher in the CCMVI with abnormal ABR group than the control and CCMVI with normal ABR groups. Cut-off values of 0.26 for EI and 0.28 for LVW/HW ratio had a sensitivity of 100% and 100%, respectively, and a specificity of 73% and 91%, respectively, for association with abnormal ABR.
Conclusions
We established a method for quantitative evaluation of ventricle size using EI and LVW/HW ratio on brain CT images in infants with CCMVI. LVW/HW ratio had a more association with abnormal ABR in the early postnatal period than EI.