3D RNA and Functional Interactions from Evolutionary Couplings
详细信息 查看全文
- 作者：Caleb Weinreb1 ; Adam J. Riesselman1 ; 4 ; John B. Ingraham1 ; Torsten Gross1 ; 2 ; Chris Sander3 ; Debora S. Marks1 ; debbie@hms.harvard.edu" class="auth_mail" title="E-mail the corresponding author
- 刊名：Cell
- 出版年：2016
- 出版时间：5 May 2016
- 年：2016
- 卷：165
- 期：4
- 页码：963-975
- 全文大小：2816 K
文摘
- •
Sequence co-evolution reveals tertiary contacts and in vivo 3D RNA structures
- •
Co-evolved contacts accurately predict the 3D structure of RNA-protein complexes
- •
Functionally critical contacts show the strongest co-evolutionary signal
- •
Predictions for 160 RNAs, including viruses and lncRNAs, hint at molecular mechanisms