Dihydromyricetin delays the onset of hyperglycemia and ameliorates insulin resistance without excessive weight gain in Zucker diabetic fatty rats

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• 作者：Lei Liu ^{liuleililian@tmmu.edu.cn} ; Jing Wan ^{wanjing1986@yeah.net} ; Hedong Lang ^{lang0401@163.com} ; Mingyu Si ^{13752914265@163.com} ; Jundong Zhu ^{zjdnfs@126.com} ; Yong Zhou ; ^{zhouyong@tmmu.edu.cn} ; Mantian Mi ; ^{mi_mt2009@hotmail.com}
• 关键词：Type 2 diabetes ; Insulin resistance ; Peroxisome proliferator-activated receptor γ ; Zucker diabetic fatty rat
• 刊名：Molecular and Cellular Endocrinology
• 出版年：2017
• 出版时间：5 January 2017
• 年：2017
• 卷：439
• 期：Complete
• 页码：105-115
• 全文大小：3067 K
• 卷排序：439

文摘

Dihydromyricetin improves insulin sensitivity of Zucker diabetic fatty rats. Dihydromyricetin does not cause excessive body weight gain in ZDF rats. The mechanism relies on reduction of PPARγ phosphorylation Ser273 via ERK/CDK5 axis.