The Phoneutria nigriventer spider toxin, PnTx4-5-5, promotes neuronal survival by blocking NMDA receptors
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- 作者：Flavia R. Silvaa ; Edleusa M.L. Batistaa ; Marcus V. Gomezb ; Christopher Kushmerickc ; Juliana F. Da Silvab ; Marta N. Cordeirod ; Luciene B. Vieirae ; Fabiola M. Ribeiroa ; fmribeiro@icb.ufmg.br" class="auth_mail" title="E-mail the corresponding author
- 关键词：NMDA receptors ; Excitotoxicity ; PnTx4-5-5 ; Amyloid β peptide ; Neuroprotection
- 刊名：Toxicon
- 出版年：2016
- 出版时间：15 March 2016
- 年：2016
- 卷：112
- 期：Complete
- 页码：16-21
- 全文大小：1027 K
文摘
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PnTx4-5-5 is a new tool to block NDMAR currents.
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PnTx4-5-5 protects neurons from both glutamate and amyloid β peptide.
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PnTx4-5-5 promotes survival of neurons from a mouse model of Huntington's disease.