Phospho-dependent Accumulation of GABABRs at Presynaptic Terminals after NMDAR Activation
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- 作者：Saad Hannan1 ; Kim Gerrow2 ; Antoine Triller2 ; Trevor G. Smart1 ; t.smart@ucl.ac.uk" class="auth_mail" title="E-mail the corresponding author
- 关键词：AMPK ; bungarotoxin binding site ; Ca2+ signaling ; excitotoxicity ; GABA receptors ; GABAB receptors ; glutamate receptors ; hippocampus ; homeostatic signaling ; lateral diffusion ; NMDA receptors ; phosphorylation ; presynaptic terminal ; quantum dots ; receptor mobility ; single-particle tracking ; sushi domains
- 刊名：Cell Reports
- 出版年：2016
- 出版时间：16 August 2016
- 年：2016
- 卷：16
- 期：7
- 页码：1962-1973
- 全文大小：3224 K
文摘
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Presynaptic GABABRs are recruited to axon terminals by lateral diffusion
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Activated GABABR1aR2 complexes become less mobile due to their sushi domains
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NMDAR activity recruits GABABRs to axon terminals by slowing their mobility
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GABABR accumulation depends on intracellular Ca2+ and phosphorylation of GABABR2S783