Rat intra-hippocampal NMDA infusion induces cell-specific damage and changes in expression of NMDA and GABAA receptor subunits
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- 作者：Lukas Rambouseka ; b ; c ; rambousek@immunology.uzh.ch" class="auth_mail" title="E-mail the corresponding author ; Lenka Kleteckovab ; c ; Anna Kubesovad ; Daniel Jirake ; f ; Karel Valesc ; d ; Jean-Marc Fritschya ; g
- 关键词：Excitotoxicity ; NMDA receptor ; GABA A receptor ; Hippocampus ; Neuroinflammation ; Neurodegeneration ; Interneurons ; Spatial learning ; Carousel maze
- 刊名：Neuropharmacology
- 出版年：2016
- 出版时间：June 2016
- 年：2016
- 卷：105
- 期：Complete
- 页码：594-606
- 全文大小：6904 K
文摘
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The infusion of NMDA induced degeneration of hippocampal principal cells.
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Neurodegeneration was accompanied with progressive and severe neuroinflammation.
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The lesion did not induce loss of GABAergic interneurons.
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GluN1 and GluN2B subunits of NMDA receptor were upregulated at early time points.
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GABAA receptor α5 subunit was downregulated at 30 days after the lesion.