Protection of neuronal cells from excitotoxicity by disrupting nNOS-PSD95 interaction with a small molecule SCR-4026
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- 作者：Shi-Fu Moa ; b ; c ; Gao-Yong Liaob ; c ; Jie Yangb ; c ; Meng-Yu Wangb ; c ; Yang Hub ; c ; Guo-Ning Lianb ; c ; Ling-Dong Konga ; kongld@nju.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Yong Zhaob ; c ; zhaoyong@mtcbiopharma.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：PSD-95 ; postsynaptic density protein-95 ; nNOS ; neuronal nitric oxide synthase ; NMDA ; N-methyl-D-aspartate ; OGD ; Oxygen and glucose deprivation ; MCAO ; middle cerebral artery occlusion ; BBB ; blood-brain barrier ; TTC ; 2 ; 3 ; 5-Triphenyltetrazolium chloride ; NSC ; Neural stem cell
- 刊名：Brain Research
- 出版年：2016
- 出版时间：1 October 2016
- 年：2016
- 卷：1648
- 期：part_PA
- 页码：250-256
- 全文大小：3543 K
文摘
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SCR-4026 disrupts nNOS-PSD-95 association with an IC50 of 6.3 μM in vitro.
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SCR-4026 shows dose-dependent neuroprotective activities in NMDA and OGD model.
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Treatment with SCR-4026 results in decreased nNOS-PSD-95 association in NMDA model.
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SCR-4026 promotes neural precursor cells to differentiate into neurons-like cells.
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Treatment with SCR-4026 alleviates brain injury in rat MCAO model.