Diazoxide enhances excitotoxicity-induced neurogenesis and attenuates neurodegeneration in the rat non-neurogenic hippocampus
详细信息 查看全文
- 作者：M. Martí ; nez-Moreno&dagger ; ; M. Batlle&Dagger ; ; F.J. Ortega§ ; ; J. Gimeno-Bayó ; n ; C. Andrade ; N. Mahy ; M.J. Rodrí ; guez ; marodriguez@ub.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：AUR ; arbitrary uniform random ; BrdU ; bromo-deoxyuridine ; CNS ; central nervous system ; DAB ; diaminobenzidine ; DG ; dentate gyrus ; DCX ; doublecortin ; DMSO ; dimethyl sulfoxide ; Dzx ; diazoxide ; GFAP ; glial fibrillary acidic protein ; HF ; hippocampal formation ; IB4 ; isolectin B4 ; KATP ; ATP-sensitive potassium ; Kir ; inwardly-rectifying potassium ; MDP ; mean deviation product ; mitoKATP ; mitochondrial KATP ; NGS ; normal goat serum ; NO ; nitric oxide ; NMDA ; N-methyl-d-aspartate ; PB ; phosphate buffer ; PBS ; pho
- 刊名：Neuroscience
- 出版年：2016
- 出版时间：1 October 2016
- 年：2016
- 卷：333
- 期：Complete
- 页码：229-243
- 全文大小：4917 K
文摘
- •
Excitotoxicity transiently enhances KATP channel expression in the rat hippocampus.
- •
Diazoxide reduces NMDA-induced neuronal loss and microglial reaction in the hippocampus.
- •
Excitotoxicity induces neurogenesis and appearance of Sp8-positive cells in the lesioned non-neurogenic hippocampus.
- •
Diazoxide enhances neurogenesis processes in the lesioned hippocampus.
- •
KATP channel modulates neurogenesis in the adult CNS under inflammatory conditions.