iTRAQ-based comparative proteomic analysis of excretory-secretory proteins of schistosomula and adult worms of Schistosoma japonicum
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- 作者：Xiaodan Caoa ; Zhiqiang Fua ; Min Zhangb ; Yanhui Hanc ; Hongxiao Hana ; Qian Hana ; Ke Lua ; Yang Honga ; hongyang_7@126.com" class="auth_mail" title="E-mail the corresponding author ; Jiaojiao Lina ; d ; jjlin@shvri.ac.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Schistosoma japonicum ; Schistosomula ; Adult worms ; iTRAQ ; Excretory/secretory proteins
- 刊名：Journal of Proteomics
- 出版年：2016
- 出版时间：14 April 2016
- 年：2016
- 卷：138
- 期：Complete
- 页码：30-39
- 全文大小：1048 K
文摘
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iTRAQ-coupled LC–MS/MS was used to investigate proteome of ESPs obtained from schistosomula and adult worms of S. japonicum.
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Bioinformatics analysis showed that differential ESPs were mainly related to stress responses and immunoregulation.
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Recombinant S. japonicum HSP70 and TPx could regulate host immune response through altering macrophage activity.