A case of rhino-orbital mucormycosis in diabetes with haematogenous cerebral spread

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• 作者：Jennifer Snaith^a ; ; Kharis Burns^a ; ^b ; Jen Kok^c ; Sharon Chen^b ; ^c ; N.Wah Cheung^a ; ^b
• 关键词：Diabetes ; Diabetic ketoacidosis ; Mucormycosis ; Adrenal insufficiency ; Posaconazole
• 刊名：Medical Mycology Case Reports
• 出版年：2016
• 出版时间：September 2016
• 年：2016
• 卷：13
• 期：Complete
• 页码：22-24
• 全文大小：295 K
• 卷排序：13

文摘

We document the first case of haematogenous cerebral spread in Rhizopus arrhizus rhino-orbital mucormycosis, and of posaconazole related adrenal insufficiency. A patient presenting with diabetic ketoacidosis and sinusitis was treated with right medial maxillectomy, ethmoidectomy and IV liposomal amphotericin. Orbital exenteration was performed after intraorbital spread of infection. IV caspofungin and posaconazole was added but complicated by adrenal insufficiency. MRI revealed a new left lentiform nucleus and thalamus rim-enhancing lesion indicating haematogenous cerebral spread.