p63 in Squamous Cell Carcinoma of the Skin: More Than a Stem Cell/Progenitor Marker

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• 作者：Caterina Missero¹ ; ² ; ^{missero@ceinge.unina.it} ; Dario Antonini³
• 刊名：Journal of Investigative Dermatology
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：137
• 期：2
• 页码：280-281
• 全文大小：106 K
• 卷排序：137

文摘

The p63 gene is often overexpressed in squamous cell carcinomas; however, how its overexpression contributes to tumor formation and expansion is still incompletely understood. Devos et al. report the development of a versatile mouse model demonstrating that p63 facilitates squamous cell carcinoma formation in skin and providing an excellent tool to dissect the relevance of its downstream signaling pathways in tumorigenesis.