Autologous Stem Cell Transplantation Promotes Mechanical Stretch Induced Skin Regeneration: A Randomized Phase I/II Clinical Trial

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• 作者：Shuang-Bai Zhou ; M.D. ; Ph.D.^a ; Guo-You Zhang ; M.D. ; Ph.D.^a ; Yun Xie ; M.D.^a ; Tao Zan ; M.D. ; Ph.D.^a ; Yao-Kai Gan ; M.D. ; Ph.D.^b ; Caroline A. Yao ; M.D. ; M.S.^c ; Cheng-An Chiang ; M.D.^a ; Jing Wang ; M.D. ; Ph.D.^a ; Kai Liu ; M.D. ; Ph.D.^a ; Hua Li ; M.D. ; Ph.D.^a ; Jia Zhou ; M.D. ; Ph.D.^a ; Mei Yang ; M.D. ; Ph.D.^a ; Bin Gu ; M.D.^a ; Feng Xie ; M.D. ; Ph.D.^a ; Lee Q. Pu ; M.D. ; Ph.D.^d ; William P. Magee III ; M.D. ; D.D.S.^c ; Qing-Feng Li ; M.D. ; Ph.D.^a ; ^{dr.liqingfeng@shsmu.edu.cn}
• 关键词：Skin regeneration ; Mechanical stretch ; Skin expansion ; Autologous stem cell ; Bone mononuclear cells
• 刊名：EBioMedicine
• 出版年：2016
• 出版时间：November 2016
• 年：2016
• 卷：13
• 期：Complete
• 页码：356-364
• 全文大小：1728 K
• 卷排序：13

文摘

This study shows that intradermally transplanted MNCs in mechanical stretched skin is a safe and feasible clinical application. Intradermally transplantation of MNCs can overcome the regenerative limitations of skin. The strategy of combining stem cell and microenvironment can provide significant amounts tissue for surgical reconstruction.Though stem cells are proved to participate in tissue regeneration, there is seldom clinical research combining stem cell and in vivo mechanotransduction to provoke skin regeneration. In this study, we introduce autologous bone marrow stem cells to mechanical stretch induced skin regeneration. The results showed that the potential of autologous stem cells in promoting skin regeneration. The application of stem cell assisted skin expansion can overcome the regenerative limitations of skin to provide significant amounts tissue for surgical reconstruction. The integration of stem cells and mechanical stretch stimuli will engender further advances in in vivo tissue regeneration.