Trauma exposure relates to heightened stress, altered amygdala morphology and deficient extinction learning: Implications for psychopathology

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• 作者：Raffaele Cacciaglia^a ; ^b ; ^{raffaele.cacciaglia@ub.edu} ; Frauke Nees^a ; Oliver Grimm^c ; Stephanie Ridder^a ; Sebastian T. Pohlack^a ; Slawomira J. Diener^a ; Claudia Liebscher^a ; Herta Flor^a ; ^{herta.flor@zi-mannheim.de}
• 关键词：Trauma ; Stress ; Amygdala ; Fear conditioning ; Extinction learning ; Post-traumatic stress disorder ; Depression
• 刊名：Psychoneuroendocrinology
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：76
• 期：Complete
• 页码：19-28
• 全文大小：1359 K
• 卷排序：76

文摘

We investigated amygdala morphology in healthy trauma-exposed individuals compared to unexposed controls. People with previous trauma exposure displayed volume increase in the left lateral amygdala compared to unexposed controls. Trauma-exposed individuals showed enhanced fear conditioning and deficient extinction, compared to healthy controls. Compared to unexposed controls, traumatized people showed salivary cortisol hypo-suppression to dexamethasone. We show multiform alterations in traumatized people which resemble symptoms of post-traumatic stress disorder and depression.