Newly acquired and reactivated contextual fear memories are more intense and prone to generalize after activation of prelimbic cortex NMDA receptors

详细信息    查看全文

• 作者：Ana C. Vanvossen^a ; Marina A.M. Portes^a ; Rafael Scoz-Silva^a ; Hugo B. Reichmann^a ; Cristina A.J. Stern^b ; Leandro J. Bertoglio^a ; ^{leandro.bertoglio@ufsc.br}
• 关键词：Fear generalization ; Medial prefrontal cortex ; Memory precision ; Extinction deficits
• 刊名：Neurobiology of Learning and Memory
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：137
• 期：Complete
• 页码：154-162
• 全文大小：1085 K
• 卷排序：137

文摘

PL cortex NMDA receptor activation induced generalized fear and extinction deficits. PL cortex NMDA receptor activation also potentiated conditioned fear expression. Similar results were obtained during consolidation, retrieval and reconsolidation. Altered PL cortex activity changes fear memory specificity and/or intensity.