Microglial production of TNF-alpha is a key element of sustained fear memory

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• 作者：Zhiqian Yu^a ; ^b ; ^c ; Hotaka Fukushima^e ; Chiaki Ono^a ; Mai Sakai^a ; ^b ; Yoshiyuki Kasahara^a ; ^b ; Yoshie Kikuchi^a ; Nicole Gunawansa^a ; Yuta Takahashi^d ; Hiroo Matsuoka^d ; Satoshi Kida^e ; Hiroaki Tomita^a ; ^b ; ^c ; ^{htomita@med.tohoku.ac.jp}
• 关键词：Fear memory ; Retention ; Extinction ; TNF-alpha
• 刊名：Brain, Behavior, and Immunity
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：59
• 期：Complete
• 页码：313-321
• 全文大小：1078 K
• 卷排序：59

文摘

Footshock-induced microglial TNF-α production remained high as fear memory retained. Microglial TNF-α returned to baseline in the process of fear memory extinction. Inhibition of TNF-α facilitated fear memory extinction. TNF-α inhibitors might be candidate remedies for posttraumatic stress disorder.