Distinction between mild cognitive impairment and Alzheimer's disease by CSF amyloid 尾₄₀ and 尾₄₂, and protein-conjugated acrolein

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• 作者：Mutsumi Mizoi^a ; ¹ ; Madoka Yoshida^a ; ¹ ; Ryotaro Saiki^a ; ^b ; Masaaki Waragai^c ; Kenichi Uemura^c ; Hiroyasu Akatsu^d ; Keiko Kashiwagi^e ; Kazuei Igarashi^a ; ^b ; ^{iga16077@faculty.chiba-u.jp" class="auth_mail}
• 关键词：Alzheimer's disease ; MCI ; MMSE ; Magnetic resonance imaging ; CSF Amyloid-尾 ; Protein-conjugated acrolein
• 刊名：Clinica Chimica Acta
• 出版年：20 March, 2014
• 年：2014
• 卷：430
• 期：Complete
• 页码：150-155
• 全文大小：448 K

文摘

Background

We found previously that the amyloid 尾_40/42 (A尾_40/42) ratio and the level of protein-conjugated acrolein (PC-Acro) in plasma were increased in mild cognitive impairment (MCI) and Alzheimer's disease (AD) subjects. We determined whether MCI and AD subjects can be differentiated based on the levels of A尾₄₀, A尾₄₂, and PC-Acro in cerebrospinal fluid (CSF).

Methods

A尾₄₀, A尾₄₂, PC-Acro, Tau and phosphorylated Tau in CSF were measured by ELISA.

Results

Median values of A尾₄₀, A尾₄₀/PC-Acro and A尾_40/42 in CSF were significantly lower in 54 AD subjects than those in 40 MCI subjects. Severity of VOI (volume of interest) atrophy was most intensely correlated with the decrease in A尾₄₀/PC-Acro and then that in A尾₄₀ and A尾₄₂/PC-Acro. MMSE was most intensely correlated with the decrease in A尾₄₂ and A尾₄₀, and then that in A尾₄₂/PC-Acro and A尾₄₀/PC-Acro.

Conclusion

A decrease in A尾₄₀/PC-Acro in CSF is well correlated with brain damage, and a decrease in A尾₄₂ and A尾₄₀ is well correlated with cognitive ability. Measurement of PC-Acro together with A尾₄₀ and A尾₄₂ provides a more precise evaluation of severity of AD subjects.