Mechanism of antiproliferative action of a new d-secoestrone-triazole derivative in cervical cancer cells and its effect on cancer cell motility

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• 作者：Noé ; mi Bó ; zsity^a ; Rená ; ta Minorics^a ; Johanna Szabó ; ^b ; Erzsé ; bet Mernyá ; k^b ; Gyula Schneider^b ; Já ; nos Wö ; lfling^b ; Hui-Chun Wang^c ; Chin-Chung Wu^c ; Imre Ocsovszki^d ; Istvá ; n Zupkó ; ^a ; ^{zupko@pharm.u-szeged.hu}
• 关键词：d-SET ; d-secoestrone-triazole ; HPV ; Human Papilloma Virus ; 2-ME ; 2-methoxyestradiol ; PAC ; paclitaxel ; Bid ; BH3 interacting-domain death agonist ; Bcl-2 ; B-cell CLL/lymphoma 2 ; FADD ; Fas-Associated protein with Death Domain ; DISC ; death-inducing signalling complex
• 刊名：The Journal of Steroid Biochemistry and Molecular Biology
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：165
• 期：part_PB
• 页码：247-257
• 全文大小：2135 K
• 卷排序：165

文摘

d-secoestrone-triazole (D-SET) inhibited the growth of cervical cancer cell lines. D-SET induced apoptosis on HeLa and C-33 A cells, with no action on SiHa cells. D-SET caused M phase blockade on HeLa cells and disrupted tubulin polymerization. D-SET inhibited migration and invasion of HeLa cells concentration dependently.