Mu-opioid receptors in the caudomedial NTS are critical for respiratory responses to stimulation of bronchopulmonary C-fibers and carotid body in conscious rats
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- 作者：Jianguo Zhuang ; Xiuping Gao ; Franklin Gao ; Fadi Xu ; MD ; fxu@lrri.org
- 关键词：Opioid ; Anesthesia ; Respiration ; Chemoreception
- 刊名：Respiratory Physiology & Neurobiology
- 出版年：2017
- 出版时间：January 2017
- 年：2017
- 卷：235
- 期：Complete
- 页码：71-78
- 全文大小：2263 K
- 卷排序：235
文摘
The cmNTS presents the highest MORs in the caudal medulla. Activation of cmNTS MORs blocks or almost eliminates the PCF-mediated apnea and HVR in the intact rats with HCVR inhibited in the carotid body ablated rats. Our data imply a presence of MORs in the synapse of the 2nd-order neurons receiving inputs from PCFs and the carotid and NTS chemosensitive neurons.