Associations between a fatty acid desaturase gene polymorphism and blood arachidonic acid compositions in Japanese elderly

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• 作者：Sayaka Horiguchi^a ; ^{hsa101@eiyo.ac.jp" class="auth_mail" title="E-mail the corresponding author} ; Kazuhiro Nakayama^b ; Sadahiko Iwamoto^b ; Akiko Ishijima^c ; Takayuki Minezaki^c ; Mamiko Baba^c ; Yoshiko Kontai^d ; Chika Horikawa^e ; Hiroshi Kawashima^e ; Hiroshi Shibata^e ; Yasuo Kagawa^a ; Terue Kawabata^a
• 关键词：ALA ; α-linolenic acid ; ARA ; arachidonic acid ; BMI ; body mass index ; DGLA ; dihomo-γ-linolenic acid ; DHA ; docosahexaenoic acid ; EPA ; eicosapentaenoic acid ; ETA ; eicosatetraenoic acid ; FADS ; fatty acid desaturase ; GLA ; γ-linolenic acid ; LA ; linoleic acid ; LCPUFA ; long chain polyunsaturated fatty acid ; PL ; phospholipid ; SNP ; single nucleotide polymorphism
• 刊名：Prostaglandins, Leukotrienes and Essential Fatty Acids
• 出版年：2016
• 出版时间：February 2016
• 年：2016
• 卷：105
• 期：Complete
• 页码：9-14
• 全文大小：312 K

文摘

We investigated whether the single nucleotide polymorphism rs174547 (T/C) of the fatty acid desaturase-1 gene, FADS1, is associated with changes in erythrocyte membrane and plasma phospholipid (PL) long-chain polyunsaturated fatty acid (LCPUFA) composition in elderly Japanese participants (n=124; 65 years or older; self-feeding and oral intake). The rs174547 C-allele carriers had significantly lower arachidonic acid (ARA; n-6 PUFA) and higher linoleic acid (LA, n-6 PUFA precursor) levels in erythrocyte membrane and plasma PL (15% and 6% ARA reduction, respectively, per C-allele), suggesting a low LA to ARA conversion rate in erythrocyte membrane and plasma PL of C-allele carriers. α-linolenic acid (n-3 PUFA precursor) levels were higher in the plasma PL of C-allele carriers, whereas levels of the n-3 LCPUFAs eicosapentaenoic acid (EPA) or docosahexaenoic acid (DHA) were unchanged in erythrocyte membrane and plasma PL. Thus, rs174547 genotypes were significantly associated with different ARA compositions of the blood of elderly Japanese.