Alteration of delta-6-desaturase (FADS2), secretory phospholipase-A2 (sPLA2) enzymes by Hot-nature diet with co-supplemented hemp seed, evening primrose oils intervention in multiple sclerosis patients
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- 作者：Soheila Rezapour-Firouzia ; b ; g ; s.rfirozi@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Seyed Rafie Arefhosseinib ; c ; arefhosseinir@tbzmed.ac.ir" class="auth_mail" title="E-mail the corresponding author ; Mehrangiz Ebrahimi-Mamaghanib ; ebrahimimamagani@tbzmed.ac.ir" class="auth_mail" title="E-mail the corresponding author ; Behzad Baradarand ; Behzad_im@yahoo.com" class="auth_mail" title="E-mail the corresponding author ; Elyar Sadeghihokmabada ; aeass@yahoo.com" class="auth_mail" title="E-mail the corresponding author ; Somaiyeh Mostafaeia ; somaiyehmostafaei@yahoo.com" class="auth_mail" title="E-mail the corresponding author ; Mohammadali Torbatie ; drtorbati@yahoo.com" class="auth_mail" title="E-mail the corresponding author ; Mahtaj Chehrehf ; mchehreh@yahoo.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：AA ; arachidonic acid ; ALA ; alpha- linolenic acid ; BBB ; blood&ndash ; brain barrier ; CNS ; central nervous system ; COX-2 ; cyclooxygenase-2 ; D6D (FADS2) ; delta -6-desaturase ; D5D (FADS1) ; delta -5-desaturase ; DGLA ; dihomo-gammalinolenic acid ; DHA ; docosa-hexanoic acid (key omega-3) ; EDSS ; extended disability status score ; EP ; evening primrose ; EPO ; evening primrose oil ; FA ; fatty acid ; FDA ; food and drug administration ; FR ; food records ; FS ; functional system ; FSS ; functional system scores ; GLA ; gamm
- 刊名：Complementary Therapies in Medicine
- 出版年：2015
- 出版时间：October 2015
- 年：2015
- 卷：23
- 期：5
- 页码：652-657
- 全文大小：558 K
文摘
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The co-supplemented oils and Hot-natured diet decreased sPLA2 concentration (sPLA2: secretory Phospholipase A2).
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There is a correlation between MS and a rapid fall of D6D activity (D6D: delta-6-desaturase).
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The co-supplemented oils and Hot-natured diet was associated with decreasing of lipid peroxidation and cell membranes damage in RRMS patients.
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The co-supplemented oils and Hot-natured diet may affect D6D activity.
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Likely, repair of myelin occurred during the early phases of disease by regulation of surface-membrane enzymes.