Linoleic acid and the pathogenesis of obesity
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- 作者：Shaan S. Naughtona ; Michael L. Mathaia ; b ; Deanne H. Hryciwc ; Andrew J. McAincha ; andrew.mcainch@vu.edu.au" class="auth_mail" title="E-mail the corresponding author
- 关键词：2-AG ; 2-arachidonyl glycerol ; 20-HETE ; 20-hydroxy-5 ; 8 ; 11 ; 14-eicosatetraenoic acid ; 9-HODE ; 9-hydroxy-octadecadienoic ; 13-HODE ; 13-hydroxy-octadecadienoic ; AA ; arachidonic acid ; AEA ; anandamide ; ALA ; α-linolenic acid ; BMI ; body mass index (kg/m2) ; cAMP ; cyclic adenosine monophosphate ; CD 68 ; cluster of differentiation 68 ; COX2 ; cyclooxygenase-2 ; CRP ; C-reactive protein ; CVD ; cardiovascular disease ; DHA ; docosahexaenoic acid ; EI ; energy intake ; EPA ; eicosapentaenoic acid ; FA ; fatty acid ; FADS1 ; fa
- 刊名：Prostaglandins and Other Lipid Mediators
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：125
- 期：Complete
- 页码：90-99
- 全文大小：1533 K
文摘
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Worldwide linoleic acid (LA) intakes have increased due to nutrition transitions.
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LA intake exceeds what is required and may have detrimental health effects.
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Excessive LA intake has been implicated in the development of obesity.
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Excessive LA may contribute to the chronic inflammatory state found in obesity.
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Genetics and maternal diet influence the effect of LA on obesity and inflammation.