mTOR as a multifunctional therapeutic target in HIV infection
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- 作者：Ferdinando Nicoletti
- 刊名：Drug Discovery Today
- 出版年：2011
- 出版时间：August 2011
- 年：2011
- 卷：16
- 期：15-16
- 页码：715-721
- 全文大小：239 K
文摘
Patients undergoing long-term highly active antiretroviral therapy treatment are probably at a higher risk of various HIV-related complications. Hyperactivation of The mammalian target of rapamycin (mTOR) has been found to contribute to dysregulated apoptosis and autophagy which determine CD4p>+ p>-T-cell loss, impaired function of innate immunity and development of neurocognitive disorders. Dysregulated mTOR activation has also been shown to play a key part in the development of nephropathy and in the pathogenesis of HIV-associated malignancies. These studies strongly support a multifunctional key role for mTOR in the pathogenesis of HIV-related disorders and suggest that specific mTOR inhibitors could represent a novel approach for the prevention and treatment of these pathologies.