Heme oxygenase-1 expression in peripheral blood mononuclear cells correlates with disease activity in multiple sclerosis
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- 作者：Paolo Fagone ; Francesco Patti ; Katia Mangano ; Santa Mammana ; Marinella Coco ; Chafia Touil-Boukoffa ; Tinatin Chikovani ; Roberto Di Marco ; Ferdin ; o Nicoletti
- 关键词：Multiple sclerosis ; HO-1 ; Autoimmunity ; IFN-beta
- 刊名：Journal of Neuroimmunology
- 出版年：2013
- 出版时间：15 August, 2013
- 年：2013
- 卷：261
- 期：1-2
- 页码：82-86
- 全文大小：401 K
文摘
Multiple sclerosis (MS) is an immunoinflammatory disease that affects the central nervous system. Heme oxygenase-1 (HO-1) is one of the three isoforms of the heme oxygenase enzyme that catabolyzes the degradation of heme into biliverdin with the production of free iron and CO. We show in this study that HO-1 expression is reduced in PBMCs of MS patients and that during exacerbation of the disease there is a significant downregulation of this enzyme. We conclude that HO-1 may play a significant role in the maintenance of immune homeostasis which is disrupted in autoimmune disorders, such as MS.