Muscle type-specific expression of Zasp52 isoforms in Drosophila

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• 作者：Anja  ; Katzemich ; Jenny Yanyan  ; Long ; Klodiana  ; Jani ; Byeo Ri  ; Lee ; Frieder  ; Schö ; ck  ; ;   ; ^{frieder.schoeck@mcgill.ca}
• 关键词：Zasp ; Drosophila ; PDZ-LIM domain protein ; Alp/Enigma family ; Alternative splicing ; Muscle attachment ; Z disk assembly ; Myofibril assembly ; Heart muscle ; Visceral muscle ; Somatic muscle
• 刊名：Gene Expression Patterns
• 出版年：2011
• 出版时间：December 2011
• 年：2011
• 卷：11
• 期：8
• 页码：484-490
• 全文大小：1483 K

文摘

Zasp52 is a member of the PDZ-LIM domain protein family in Drosophila, which comprises Enigma, ENH, ZASP, Alp, CLP36, RIL, and Mystique in vertebrates. Drosophila Zasp52 colocalizes with integrins at myotendinous junctions and with ¦Á-actinin at Z-disks, and is required for muscle attachment as well as Z-disk assembly and maintenance. Here we document 13 Zasp52 splice variants giving rise to six different LIM domains. We demonstrate stage- and tissue-specific expression in different muscle types for Zasp52 isoforms encoding different LIM domains. In particular, LIM1b is expressed only in heart muscle and certain somatic muscles, implying muscle-specific functions in Z-disk assembly or maintenance.