Targeted delivery of doxorubicin to breast cancer cells by magnetic LHRH chitosan bioconjugated nanoparticles
详细信息 查看全文
- 作者：Jaleh Varshosaza ; varshosaz@pharm.mui.ac.ir" class="auth_mail" title="E-mail the corresponding author ; Farshid Hassanzadehb ; Hojat Sadeghi Aliabadic ; Fatemeh Rabbani Khoraskania ; Mina Mirianc ; Behshid Behdadfard
- 关键词：Magnetic nanoparticles ; Doxorubicin hydrochloride ; Chitosan-poly(methyl vinyl maleic acid) ; LHRH ; Breast cancer
- 刊名：International Journal of Biological Macromolecules
- 出版年：2016
- 出版时间：December 2016
- 年：2016
- 卷：93
- 期：part_PA
- 页码：1192-1205
- 全文大小：3119 K
文摘
- •
Bioconjugate of LHRH-chitosan-poly(methyl vinyl ether maleic acid) was synthesized.
- •
Polysaccharide nanoparticles were prepared by a layer-by-layer technique.
- •
Nanoparticles were loaded with magnetic nanoparticles and doxorubicin.
- •
The nanoparticles were targeted by synthesized LHRH bioconjugate.
- •
The targeted nanoparticles reduced IC50 of drug 2 fold in LHRH positive cancer cells.