Nesfatin-1 as a new positive inotrope in the goldfish (Carassius auratus) heart
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- 作者：R. Mazza1 ; A. Gattuso1 ; M. Filice ; P. Cantafio ; M.C. Cerra ; T. Angelone ; S. Imbrogno ; sandra.imbrogno@unical.it" class="auth_mail" title="E-mail the corresponding author
- 关键词：AC ; adenylate cyclase ; β-AR ; beta adrenergic receptor ; BSA ; bovine serum albumin ; CO ; cardiac output ; ERK1/2 ; extracellular signal-regulated kinases1/2 ; GAPDH ; Glyceraldehyde-3-Phosphate Dehydrogenase ; HCNP ; hippocampal cholinergic neurostimulating peptide ; HR ; heart rate ; ISO ; Isoproterenol ; NLT ; nucleus lateralis tuberis ; NUCB2 ; nucleobindin-2 ; pERK1/2 ; phosphorylated ERK1/2 ; PLN ; phospholamban ; pPLN ; phosphorylated PLN ; PKA ; cAMP dependent kinase ; SV ; stroke volume ; SW ; stroke work
- 刊名：General and Comparative Endocrinology
- 出版年：2015
- 出版时间：1 December 2015
- 年：2015
- 卷：224
- 期：Complete
- 页码：160-167
- 全文大小：877 K
文摘
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Nesfatin-1 potentiates the mechanical performance of the in vitro goldfish heart.
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Nesfatin-1-elicited inotropism is mediated by a cAMP-dependent pathway.
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Nesfatin-1-induced cardiostimulation involves ERK1/2 and phospholamban.