The article is devoted to results of the study of peculiarities of genesis and transformation of the research theory and methods in neo-Kantian conceptualization of science. On the basis of the empirical investigation of publication of periodical issues it is stated that the change in the paradigm of applied philosophy and psychology is concluded in organic cohesion of their categorical structure with gnoseological idea, taken from the outlook of the epoch and defining the peculiarities of scientific picture of the world in the moment of the birth of new methodological directions.