Apolipoprotein E Genotypes Associated with Alzheimer Disease and Concomitant Stroke

详细信息    查看全文

• 作者：Najiba Fekih-Mrissa ; PhD^&lowast ; ; ^&dagger ; ; ^{fnajiba@yahoo.fr" class="auth_mail} ; Sarra Klai ; PhD^&lowast ; ; ^&Dagger ; ; Meriem Mrad ; PhD^&lowast ; ; ^&Dagger ; ; Malek Mansour ; MD^§ ; ; ^|| ; Jamel Zaouali ; MD^§ ; ; ^|| ; Nasreddine Gritli ; PhD^&lowast ; ; ^¶ ; ; Ridha Mrissa ; MD^§ ; ; ^||
• 关键词：Apolipoprotein E ; Alzheimer disease ; stroke ; risk factor ; genotyping
• 刊名：Journal of Stroke and Cerebrovascular Diseases
• 出版年：April, 2014
• 年：2014
• 卷：23
• 期：4
• 页码：681-685
• 全文大小：115 K

文摘

| Figures/TablesFigures/Tables | ReferencesReferences

Background

The 蓻4 allele of the apolipoprotein E (APOE) gene is a well-characterized genetic risk factor for Alzheimer disease (AD). The association between stroke and a higher risk for AD has also been reported. Our study sought to determine the relationship between the APOE gene and AD and the comorbid risk of stroke.

Methods

The subjects of this study consisted of 48 patients with AD and 48 members of a control group. All subjects were genotyped for APOE.

Results

The results clearly show a significant increased risk of AD in carriers of the APOE 蔚3/蔚4 genotype (P聽=聽.003, odds ratio [OR]聽=聽4.1) or 蔚4 allele (P聽=聽.001, OR聽=聽4.2). The risk for stroke in AD patients was also increased for carriers of the APOE 蔚3/蔚4 genotype (P = .02, OR聽=聽9.0) and for carriers of the APOE 蔚4 allele (P聽= .004, OR聽=聽5.5).

Conclusions

The present study is the first to establish a relationship between APOE 蔚4 and concomitant AD and stroke in the Tunisian population.