Glaucoma in the Early Treatment for Retinopathy of Prematurity (ETROP) study

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• 作者：Don L. Bremer ; MD^a ; David L. Rogers ; MD^a ; ^{david.rogers@nationwidechildrens.org} ; William V. Good ; MD^b ; Betty Tung ; MS^c ; Robert J. Hardy ; PhD^c ; Rae Fellows ; MEd^a
• 刊名：Journal of American Association for Pediatric Ophthalmology and Strabismus
• 出版年：2012
• 出版时间：October, 2012
• 年：2012
• 卷：16
• 期：5
• 页码：449-452
• 全文大小：71 K

文摘

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Purpose

To report the clinical characteristics of infants with severe retinopathy of prematurity (ROP) and glaucoma-based on review of the Early Treatment for Retinopathy of Prematurity (ETROP) study.

Methods

All infants randomized in the ETROP trial were included. Each infant developed high-risk prethreshold ROP in at least one eye. Infants were examined until 6 years postnatal age. The following data were collected: corneal clarity, depth of the anterior chamber, status of the optic nerve and cup/disk ratio, retinal structure, and visual acuity. The diagnosis of glaucoma was based on the investigators best clinical judgment. All infants diagnosed with glaucoma were included in the study.

Results

A total of 12 of 718 eyes (1.67 % ) were diagnosed with glaucoma. Of these, 5 were first reported as having glaucoma at 9 months, 2 at 2 years, 1 each at 3 and 4 years, and 3 at 5 years. The anterior segment was shallow in 7 eyes. Three eyes had normal retinal structure, 1 had macular dragging, and 8 had retinal detachments involving the fovea (stage 4B or worse). At the 6-year follow-up examination only one eye with glaucoma had measurable vision.

Conclusions

Although earlier treatment of significant ROP has resulted in better retinal structure and visual acuity outcomes, nearly 2 % of the eyes with high-risk prethreshold ROP developed glaucoma at some point during the first 6 years of life.