Libertellenones A–D: Induction of cytotoxic diterpenoid biosynthesis by marine microbial competition

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• 作者：Dong-Chan Oh ; Paul R. Jensen ; Christopher A. Kauffman and William Fenical
• 关键词：Co-culture ; Induction of biosynthesis ; Libertellenones
• 刊名：Bioorganic and Medicinal Chemistry
• 出版年：2005
• 出版时间：2005
• 年：2005
• 卷：13
• 期：17
• 页码：5267-5273
• 全文大小：259 K

文摘

The induction of biosynthesis of four new diterpenoids was observed following the addition of a marine α-proteobacterium to an established culture of the marine-derived fungus Libertella sp. The fungal strain and the marine bacterium, cultured alone, do not produce diterpenoid metabolites. The induced diterpenoids, libertellenones A–D, are cross-conjugated ketones of the pimarane class. The libertellenones show varying levels of cytotoxicity against the HCT-116 human adenocarcinoma cell line with libertellenone D being the most potent (IC₅₀ = 0.76 μM).