Fetuin-A and risk of CVD was prospectively examined in a multi-ethnic population.
No overall association between serum fetuin-A and CVD events was found.
The association of fetuin-A with risk of CVD was found to depend on glycemic status.
Fetuin-A tended to be inversely associated with CVD events in normoglycemic persons.
Fetuin-A was directly associated in those with impaired fasting glucose or diabetes.