Nuclear receptor corepressors Ncor1 and Ncor2 (Smrt) are required for retinoic acid-dependent repression of Fgf8 during somitogenesis
详细信息 查看全文
- 作者：Sandeep Kumar1 ; Thomas J. Cunningham1 ; Gregg Duester ; duester@SBPdiscovery.org" class="auth_mail" title="E-mail the corresponding author
- 关键词：Caudal progenitors ; Somitogenesis ; Nuclear receptor corepressor ; NCOR ; SMRT ; Fgf8 ; Retinoic acid response element ; CRISPR/Cas9 gene editing
- 刊名：Developmental Biology
- 出版年：2016
- 出版时间：1 October 2016
- 年：2016
- 卷：418
- 期：1
- 页码：204-215
- 全文大小：5307 K
文摘
- •
Genetic loss of Ncor1 and Ncor2 results in ectopic Fgf8 expression and small somites.
- •
NCOR1/2 corepressors, but not coactivators, are recruited to the Fgf8 RARE by RA.
- •
Genomic deletion of Fgf8 RARE with CRISPR/Cas9 often results in small somite defect.
- •
Nuclear receptor corepressors NCOR1 and NCOR2 mediate RA-dependent Fgf8 repression.