Negative Fgf8-Bmp2 feed-back is regulated by miR-130 during early cardiac specification
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- 作者：Carmen Lopez-Sancheza ; Diego Francob ; Fernando Bonetb ; Virginio Garcia-Lopezc ; Amelia Aranegab ; Virginio Garcia-Martineza ; virginio@unex.es" class="auth_mail" title="E-mail the corresponding author
- 关键词：Cardiac specification ; Electroporation ; MiR-130 ; Bmp2 ; Fgf8
- 刊名：Developmental Biology
- 出版年：2015
- 出版时间：1 October 2015
- 年：2015
- 卷：406
- 期：1
- 页码：63-73
- 全文大小：4557 K
文摘
Negative Fgf8-Bmp2 feed-back is regulated by miR-130 during early cardiac specification, by Lopez-Sanchez et al. miR-130 Regulates the earliest specific cardiac markers Nkx-2.5 and Gata4.
Bmp2 regulates miR-130 -a putative microRNA that targets Erk1/2 (Mapk1) 3′UTR.
Bmp2 regulates Fgf8 expression through miR-130.
Fgf8 suppresses Bmp2 signaling during early cardiogenesis.
miR-130 constitutes a key factor during early cardiac specification.