Gender differences of B cell signature related to estrogen-induced IFI44L/BAFF in systemic lupus erythematosus

详细信息    查看全文

• 作者：Hongye Fan^a ; ^c ; Guangfeng Zhao^b ; ^{zgfwindman@gmail.com} ; Deshan Ren^c ; Fei Liu^c ; Guanjun Dong^c ; Yayi Hou^c ; ^{yayihou@nju.edu.cn}
• 关键词：Systemic lupus erythematosus ; B cells ; Gender difference ; IFI44L
• 刊名：Immunology Letters
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：181
• 期：Complete
• 页码：71-78
• 全文大小：2399 K
• 卷排序：181

文摘

Gene trendline of SLE female is higher than that of SLE male;. There are more differentially expressed genes in SLE male vs healthy male than these in SLE female vs healthy female;. Estrogen-induced IFI44L/BAFF contributes to the difference between SLE male and female. Diagnosis and treatment of these immune-related diseases should consider the baseline gender-related differences.