Quality of life in stable schizophrenia: The relative contributions of disorganization and cognitive dysfunction

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• 作者：Monica Sigaudo ; Barbara Crivelli ; Filomena Castagna ; Michela Giugiario ; Cinzia Mingrone ; Cristiana Montemagni ; Giuseppe Rocca ; Paola Rocca ; ^{paola.rocca@unito.it" class="auth_mail}
• 关键词：Schizophrenia ; Quality of life ; Disorganization ; Cognitive dysfunction ; Mediation analysis
• 刊名：Schizophrenia Research
• 出版年：March, 2014
• 年：2014
• 卷：153
• 期：1-3
• 页码：196-203
• 全文大小：379 K

文摘

Objective

The purpose of this study was to examine the relative contributions of disorganization and cognitive dysfunction to quality of life (QOL) in patients with stable schizophrenia.

Methods

A total of 276 consecutive outpatients with stable schizophrenia were enrolled in a cross-sectional study. We performed a mediation analysis to assess the specific effect of disorganization on QOL, as assessed by the Heinrichs-Carpenter Quality of Life Scale (QLS), and the possible mediating role of cognitive dysfunction.

Results

Our findings were as follows: (i) disorganization was negatively related to the total QLS score; (ii) disorganization was negatively related to two of the four QLS domains, namely the role-functioning domain (occupational/educational) and the intrapsychic functioning domain (e.g., motivation, curiosity, and empathy); and (iii) verbal memory was a partial mediator of the relationship between disorganization and QLS (the total score and the two above-mentioned domains).

Conclusions

Disorganization demonstrated direct and indirect effects via verbal memory on two domains of functioning, as measured by the QLS. These results highlight the importance of improving disorganization and cognition (particularly verbal memory) to improve the functional outcomes of patients with schizophrenia.