Structures of G protein-coupled receptors reveal new opportunities for drug discovery
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- 作者：Robert M. Cooke ; Alastair J.H. Brown ; Fiona H. Marshall ; Jonathan S. Mason ; jon.mason@heptares.com" class="auth_mail" title="E-mail the corresponding author ; drugdesign@email.com" class="auth_mail" title="E-mail the corresponding author
- 刊名：Drug Discovery Today
- 出版年：2015
- 出版时间：November 2015
- 年：2015
- 卷：20
- 期：11
- 页码：1355-1364
- 全文大小：2295 K
文摘
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X-ray structures are now available for more than 60 ligands and 20 GPCRs.
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Structures reveal details of ligand biding that could not be predicted.
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Structure-based drug design for GPCRs has been transformed by the new results.
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Lipophilic sites and water molecules have key roles in ligand-binding properties.