Neutrophil-Derived IL-1β Impairs the Efficacy of NF-κB Inhibitors against Lung Cancer
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- 作者：Allyson G. McLoed1 ; Taylor P. Sherrill2 ; Dong-Sheng Cheng2 ; Wei Han2 ; Jamie A. Saxon1 ; Linda A. Gleaves2 ; Pingsheng Wu3 ; Vasiliy V. Polosukhin2 ; Michael Karin4 ; Fiona E. Yull1 ; 5 ; Georgios T. Stathopoulos2 ; 6 ; 7 ; Vassilis Georgoulias8 ; Rinat Zaynagetdinov2 ; 11 ; rinat.z.zaynagetdinov@vanderbilt.edu" class="auth_mail" title="E-mail the corresponding author ; Timothy S. Blackwell1 ; 2 ; 5 ; 9 ; 10 ; 11
- 刊名：Cell Reports
- 出版年：2016
- 出版时间：28 June 2016
- 年：2016
- 卷：16
- 期：1
- 页码：120-132
- 全文大小：3302 K
文摘
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Inhibition of NF-κB signaling in myeloid cells enhances lung tumorigenesis
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Carcinogen treatment induces IL-1β processing in neutrophils with NF-κB inhibition
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NF-κB targeting with bortezomib increases IL-1β production in NSCLC patients
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Combination therapy with bortezomib and IL-1R antagonist slows tumor growth in mice