Polymerase ε (POLE) ultra-mutation in uterine tumors correlates with T lymphocyte infiltration and increased resistance to platinum-based chemotherapy in vitro

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• 作者：Stefania Bellone^a ; Eliana Bignotti^b ; Silvia Lonardi^c ; Francesca Ferrari^a ; Floriana Centritto^a ; Alice Masserdotti^a ; Francesca Pettinella^a ; Jonathan Black^a ; Gulden Menderes^a ; Gary Altwerger^a ; Pei Hui^d ; Salvatore Lopez^e ; Christopher de Haydu^a ; Elena Bonazzoli^a ; Federica Predolini^a ; Luca Zammataro^a ; Emiliano Cocco^a ; Federico Ferrari^b ; Antonella Ravaggi^f ; Chiara Romani^f ; Fabio Facchetti^c ; Enrico Sartori^g ; Franco E. Odicino^g ; Dan-Arin Silasi^a ; Babak Litkouhi^a ; Elena Ratner^a ; Masoud Azodi^a ; Peter E. Schwartz^a ; Alessandro D. Santin^a ; ^{alessandro.santin@yale.edu}
• 关键词：POLE ; polymerase ε ; CTL ; cytotoxic T lymphocytes ; USC ; uterine serous carcinoma
• 刊名：Gynecologic Oncology
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：144
• 期：1
• 页码：146-152
• 全文大小：869 K
• 卷排序：144

文摘

Up to 12% of endometrial cancers are ultra-mutated secondary to polymerase-ε (POLE) mutations. POLE (+) tumors are heavily infiltrated with CD4 +/CD8 + TIL and overexpress PD1 immune-check-point. POLE ultra-mutated tumors are more resistant to platinum chemotherapy.