The use of ductal lavage as a screening tool in women at high risk for developing breast carcinoma

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• 作者：Catherine D. Carruthers ; Lori A. Chapleskie ; Mary Beth Flynn ; Thomas G. Frazier
• 关键词：Breast cancer ; Ductal lavage ; High-risk stratification
• 刊名：The American Journal of Surgery
• 出版年：2007
• 出版时间：October 2007
• 年：2007
• 卷：194
• 期：4
• 页码：463-466
• 全文大小：112 K

文摘

The purpose of the study was to determine if ductal lavage could predict the occurrence of breast cancer as well as further stratify patients at high-risk for developing breast cancer.

Methods

Ductal lavage was performed in 116 high-risk patients (Gail Risk score ≥1.7 % , previous breast cancer, strong family history, previous suspicious biopsy specimen). If atypia or papillary cells were identified, a standard protocol of evaluation was initiated.

Results

Two hundred twenty-three lavages were performed on 116 patients. Twenty-seven lavages in 25 patients yielded atypical or papillary-like cells. The 15 patients who underwent further evaluation for atypia had no evidence of cancerous or precancerous lesions. All patients were followed-up: 2 developed breast cancer, both of whom had had normal previous lavage. No patient with abnormal lavage developed cancer during follow-up.

Conclusions

We find ductal lavage to be of limited value in the screening of high-risk patients and have removed it from our treatment algorithm.