Label-free femtomolar cancer biomarker detection in human serum using graphene-coated surface plasmon resonance chips
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- 作者：Lijie Hea ; b ; Quentin Pagneuxa ; Iban Larrouletc ; Aritz Yanguas Serranoc ; Amaia Pesquerad ; Amaia Zurutuzad ; Daniel Mandlerb ; Rabah Boukherrouba ; Sabine Szuneritsa ; sabine.szunerits@iri.univ-lille1.fr" class="auth_mail" title="E-mail the corresponding author
- 关键词：Graphene ; SPR ; Folic acid protein ; Folate receptor ; Folic acid ; Biomarker
- 刊名：Biosensors and Bioelectronics
- 出版年：2017
- 出版时间：15 March 2017
- 年：2017
- 卷：89
- 期：part_P1
- 页码：606-611
- 全文大小：234 K
文摘
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The use of CVD graphene coated SPR chips for biomarker sensing is proposed.
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The integration of folic acid allows for the sensing of folic acid proteins.
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A detection limit of 5 fM for folic acid proteins was achieved.
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Sensing in human serum is possible as an anti-fouling strategy was developed.