Serum folate concentrations and all-cause, cardiovascular disease and cancer mortality: A cohort study based on 1999-2010 National Health and Nutrition Examination Survey (NHANES)

详细信息    查看全文

• 作者：Yang Peng ; ^{yang.peng@uq.net.au" class="auth_mail" title="E-mail the corresponding author} ; Bin Dong ; Zhiqiang Wang
• 关键词：Folate ; Mortality ; NHANES
• 刊名：International Journal of Cardiology
• 出版年：2016
• 出版时间：15 September 2016
• 年：2016
• 卷：219
• 期：Complete
• 页码：136-142
• 全文大小：1187 K

文摘

The relationships between serum folate levels and all-cause, cardiovascular disease (CVD), and cancer mortality are controversial.

Methods

Utilizing 1999–2010 National Health and Nutrition Examination Survey (NHANES) and linked mortality data, we performed a cohort study with 28,845 participants and used Cox proportional hazards models and restricted cubic spline plots to elucidate the dose–response relationships between serum folate status and all-cause, CVD and cancer mortality.

Results

During an average follow-up for 6.2 years, 2821, 545 and 628 deaths were attributed to all-causes, CVD and cancer, respectively. Lower folate levels were associated with increased mortality, with hazards ratios of 1.30 (95% confidence interval [CI]: 1.16–1.47) for all-cause mortality, 1.33 (95% CI: 1.01–1.76) for CVD mortality, and 1.47 (95% CI: 1.16–1.87) for cancer mortality (first quartiles versus second quartiles). A reversed J-shaped pattern was apparently observed in males and younger participants when analyzing all-cause mortality and in younger participants when it comes to CVD and cancer mortality.

Conclusions

Lower folate levels, but not restricted to folate deficiency, are linked with higher rates of all-cause, CVD and cancer mortality. Adverse effects of excess folate as well as age and gender differences on mortality need further investigation.