Association between cerebrospinal fluid dopamine concentrations and catechol-O-methyltransferase gene polymorphisms in forensic autopsy cases of methamphetamine abusers

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• 作者：Aya Matsusue^a ; ^{miyoshi@fukuoka-u.ac.jp} ; Takaki Ishikawa^b ; Tomomi Michiue^b ; Brian Waters^a ; Kenji Hara^a ; Masayuki Kashiwagi^a ; Mio Takayama^a ; Natsuki Ikematsu^a ; Shin-ichi Kubo^a
• 关键词：Methamphetamine ; Catechol-O-methyltransferase ; Polymorphism ; Cerebrospinal fluid ; Dopamine
• 刊名：Forensic Science International
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：270
• 期：Complete
• 页码：159-164
• 全文大小：488 K
• 卷排序：270

文摘

Catecholamine concentrations were measured in the cerebrospinal fluid (CSF) of drug abusers. The COMT polymorphisms, rs4633 and rs4680 were identified among drug abusers. COMT polymorphisms correlated with CSF dopamine (DA) concentrations in methamphetamine abusers. COMT polymorphisms did not correlate with CSF DA concentrations in fatal psychotropic cases. COMT polymorphisms were not associated with Adr or Nad concentrations in the CSF of drug abusers.